I will be jaded and cynical about it, however.
That's about what I would expect from you.
Really the only logical place for an OP3 to start would be to start over in an alternate continuity, or following another group of survivors (could be another ship, Earth-based survivors who waited it out in stasis deep underground or in orbit, or colonists on Mars/the moon/Titan/some other place in the solar system).
I had often thought about the waiting it out in orbit idea. Even for New Terra that could work. With the blight's rate of expansion, you'd think it'd eventually starve itself out. With only a partially complete spaceship in orbit, you could potentially evacuate enough people there, put them in stasis, forget about building an engine, and just wait. If you want to add some darkness to the story, maybe the hastily built spaceship of the winning colony explodes upon launch, taking the best and brightest of humanity with them. The cruft left behind who didn't earn a seat on the completed spaceship are then left to try to survive on the partially built spaceship of the losing colony.
But yeah, just a reboot with an alternative story, and an updated game engine sounds like the most likely way to continue.
As for the FPS idea brought up, that has potentially for quite a lot of darkness. Exterminate the last vestiges of humanity! Collect 200 "points" to win!
Or you could have the savants go the route of HAL or GLaDOS. Lots of possibility for dark humor there. And science!
**: Colonist assigned to air-lock maintenance. Opening air-lock. "Wait! No! Arrrrgh! Gasp! *choke*". -- Sudden decompression sucks.
Science: Did you know that colonists kept in an oxygenated environment are far more likely to die of cancer than those kept in an oxygen free environment?