Umm..., ahh, almost misunderstood the question. The version on Outpost 2 from the site runs in windowed mode, so it makes no attempt to change the resolution. Hence it will run at whatever the resolution your desktop is set to.
This does of course mean you can resize the window, making those buttons not so far away, but it won't do much to help readability. Maybe play with the font size or DPI settings under Windows? Mind you, that's still a global effect. (Right-click on desktop -> Properties: Play with the Font Size on the Appearances Tab, or go to the Settings Tab -> Advanced -> General Tab -> DPI).
I can't really think of any suggestions that are Outpost 2 specific. Mind you, if small fonts are frequently an issue, knowing about those 2 options can be nice.