Depends on what side I'm playing.
As Eden, the best way to destroy my enemy are many Thor's Hammer Tigers. This 'iron storm' almost literally crushes all opposition sent against me... but it's not entirely THTs- I throw in some EMPs, Acid Clouds, and maybe a Laser Tiger or two (to mow down spiders). This is the winning strategy I have for Eden on, say, Starship CG (Or reclaiming the origional colony area on population).
I can't say I've developed a winning strategy for Plymouth... rushing the base early with Microwave Lynxes before they become entrenched seems to be the best strategy (on Starship II anyway...). Though I'd have to say whenever I'm on the defensive, my first targets are Acid Clouds, the EMP, Rail Gun, and then Laser lynxes. My spiders keep dying too much for EMP + Spiders to be truly effective.
:op2: